Horizontal holes ar not ok to be rounded. Best to use this romboid cylinder to make a hole suited for 3d printing.
The model can be added to Prusa Slicer gallery and used as negative volume.
Adding to gallery:


After that, it can be added as a negative volume:

Then you cand resize it, but first disable scaling (click on the lock icon to unlock it):

result:

The author marked this model as their own original creation.