The new mounting holes should be pretty universal, if the mounting latches of your new speaker are too wide, you can add a negative modifier in Prusa Slicer adjacent to the existing cutouts I have put into the model.
The holes for the speaker are sized for M4 heat set inserts.
Printed 180% rotated on the Y axis, with classic supports enabled; 4 outer walls, 45% infill, worked perfectly.
If your existing speaker doesn't have the foam gasket anymore due to detoriation, you can use the dampener file to print one out of TPU.
The author marked this model as their own original creation.